Products Description
Pharmaceutical grade Dichloromethane Manufacturer in China | CAS 75-09-2 Bulk Supply
Dichloromethane DCM is a geminal organic compound and is also called Methylene chloride or Methylene dichloride. Methylene chloride is a colourless liquid which has a sweet, penetrating, ether-like smell. It is a volatile liquid chlorinated hydrocarbon. It is non-combustible but if exposed to high temperatures it may produce toxic chloride fumes. At higher concentrations vapours are narcotic. DCM serves as a powerful industrial solvent across pharmaceutical, laboratory, and manufacturing sectors.
Dichloromethane is a critical solvent in pharmaceutical industry. It plays a key role in extracting, purifying and synthesizing a range of drugs such as steroids, antibiotics and vitamins.
For further details, please feel free to contact us. 📨Email: sales@gneebio.com
Specification
| Parameter | Unit | Specification (Pharma Grade) |
|---|---|---|
| Product Name | - | Dichloromethane (Methylene Chloride / DCM) |
| CAS Number | - | 75-09-2 |
| EC Number | - | 200-838-9 |
| Molecular Formula | - | CH₂Cl₂ |
| Molecular Weight | g/mol | 84.93 |
| Purity | % | ≥ 99.95 |
| Appearance | - | Clear, colorless liquid |
| Odor | - | Characteristic mild ether-like odor |
| Color (APHA) | APHA | ≤ 10 |
| Water Content | % | ≤ 0.015 |
| Acidity (as HCl) | % | ≤ 0.0005 |
| Residue on Evaporation | % | ≤ 0.001 (typical specification) |
| Boiling Point | °C | 39.6 |
| Melting Point | °C | -97 |
| Density (20°C) | g/cm³ | 1.325 – 1.330 |
| Solubility in Water | - | Slightly soluble |
| UN Number | - | UN 1593 |
| Hazard Class | - | 6.1 (Toxic substance) |
| Packing Group | - | III |
Key Properties & Why They Matter for Pharma
1. Superior Solubility
Dichloromethane (DCM) dissolves a wide variety of organic compounds, including polymers, resins, natural products, and synthetic intermediates. DCM is one of the most widely used chlorinated solvents. In pharmaceutical manufacturing, this translates to higher extraction rates and more efficient purification processes.
2. Low Boiling Point (39.6°C)
Due to its near-body boiling point, DCM evaporates rapidly and can be easily removed from the final product by simple distillation or vacuum drying. This is crucial for minimizing residual solvent content in active pharmaceutical ingredients (APIs) and ensuring compliance with ICH Q3C guidelines regarding residual solvents.
3. Non-Flammable
Unlike many organic solvents such as ethanol, acetone, or ethyl acetate, methylene chloride is not classified as flammable in the GHS and has no flash point under standard conditions. This significantly reduces the risk of fire and explosion in production facilities, especially in high-volume production environments.
Dichloromethane Chemical For Pharmaceutical Industry
Pharmaceutical-grade Dichloromethane DCM liquid is widely used in pharmaceutical manufacturing as a versatile process solvent for API extraction, organic synthesis, and formulation development.
1. API Extraction and Purification
DCM is the preferred solvent for extracting active pharmaceutical ingredients from natural sources. Its strong dissolving power efficiently separates target compounds such as alkaloids, steroids, and flavonoids, while its low boiling point allows for gentle solvent removal without damaging heat-sensitive molecules.
Applications include:
- Extraction of natural products from medicinal plants
- Recovery of fermentation products
- Liquid-liquid extraction in downstream processes
- Chromatographic purification of active pharmaceutical ingredients
2. Chemical Synthesis and Reaction Medium
As a chemically inert and highly dissolving solvent, methylene chloride is an ideal reaction medium for many drug synthesis routes. It is used in the synthesis of drugs including antibiotics, vitamins, and steroid intermediates.
- Peptide synthesis and coupling reactions
- Chiral resolution processes
- Redox reactions
- Protective and deprotective steps in organic synthesis
- Production of pharmaceutical intermediates
3. Tablet Coating Applications
Used as a solvent system for polymer-based film coating formulations, helping to achieve uniform coating layers and efficient solvent evaporation.
4. Microencapsulation Processes
DCM is applied in controlled formulation development where encapsulation of active ingredients is required for modified release systems.
5. Analytical and Laboratory Uses
Dichloromethane (CAS 75-09-2) is an essential reagent in pharmaceutical analysis laboratories, used for sample preparation, extraction in HPLC and GC-MS analysis, and as a reference solvent in spectroscopic methods.
- Related articles: Why Is Dichloromethane DCM Solvent (CAS No.75-09-2) Used In Pharmaceutical Industry?
Request Full SDS, COA or free DCM samples
Packaging
We offer flexible packaging options to meet your different needs:
Company Profile
Gneebio is a professional supplier of chemical raw materials with over a decade of experience in international trade. The company specializes in the production and export of industrial chemicals, organic solvents, pharmaceutical intermediates, and fine chemicals, serving clients across the global pharmaceutical, coatings, agrochemical, electronics, and manufacturing sectors.
Our best-selling products include: Dichloromethane; Acetic acid; Methyl Sulfoxide; Methyl Sulfoxide DMSO (Industrial and pharmaceutical grade); Ethylene Glycol; Isopropanol; 1-Propanol; p-Xylene, etc.
FAQ
Q1: Could you offer sample?
A1: Yes,sample is available. We can send samples by couriers or air as client's requirements.
Q2: What is MOQ?
A2: It usually does not have MOQ requirement. We will offer the most cost-effective solution including price and delivery way according to purchasing quantities.
Q3: What is the delivery time?
A3: For non-hazardous,it usually has stock. It can be sent within 7 days. For hazardous chemical,it may be 1~2 weeks. If it is our regular product, the time will be earlier.
Q4: Can you provide relevant documents?
A4: Of course. Bill of loading,Commercial Invoice, Packing List, Origin of Certificate , insurance, COA and SDS are available.
Q5: Do you accept third party inspection?
A5: Yes,we do.
Q6: What is your payment term?
A6: TT,LC,Paypal,Western Union, ACH wire are available.
Hot Tags: High Purity DCM Dichloromethane For Pharmaceutical Industry CAS 75-09-2, China High Purity DCM Dichloromethane For Pharmaceutical Industry CAS 75-09-2 manufacturers, suppliers, factory, organic chemicals, organic chemical suppliers, high quality organic chemicals, bulk organic chemicals