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Is diethylene glycol (CAS 111-46-6) more toxic than ethylene glycol (CAS 107-21-1)?

Nov 14, 2025 Leave a message

Is diethylene glycol (CAS 111-46-6) more toxic than ethylene glycol (CAS 107-21-1)?

Both Diethylene Glycol (DEG) and Ethylene Glycol (EG) are highly toxic and can be fatal if ingested.

 

Diethylene glycol has "moderate to low" acute toxicity in animal experiments. The LD50 for small mammals is between 2 and 25 g/kg, less toxic than its relative ethylene glycol but still capable of causing toxicity in humans (in high concentrations only).

 

Feature Ethylene Glycol (CAS 107-21-1) Diethylene Glycol (CAS 111-46-6)
Common Use Main ingredient in automotive antifreeze. Industrial solvent and chemical ingredient.
Toxicity Level Highly Toxic Highly Toxic
Primary Danger Kidney failure from crystal formation. Severe kidney failure from direct damage.

 

Safety information:

1. Diethylene glycol is toxic to humans and long-term exposure may lead to poisoning. Avoid inhaling it or coming into contact with your skin.

2. Follow safe operating procedures during use, such as wearing protective gloves, goggles and clothing.

3. Store in a tightly sealed container, away from fire and oxidisers.

4. If an accident or leak occurs, take appropriate emergency measures immediately, such as ventilating the area and isolating the leaked material, to prevent its spread and minimise harm.

 

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Packaging 

Galvanized iron drum packing : 180kgs per drum,14.4tons per 20'FCL
 

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Storage condistion

Store in a cool, ventilated and dry place, avoid sunlight, and do not get close to the fire source. Pay attention to handle with care when handling, and transport according to the provisions of toxic substances

 

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