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Is dimethyl carbonate DMC chemical hazardous?

Dec 23, 2025 Leave a message

CAS 616-38-6 Dimethyl carbonate (DMC) is an organic compound with the formula OC(OCH3)2. It is a colourless, flammable liquid. It is classified as a carbonate ester. This compound has found use as a methylating agent and more recently as a solvent that is exempt from the restrictions placed on most volatile organic compounds (VOCs) in the US.Dimethyl carbonate is often considered to be a green reagent.

 

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Is dimethyl carbonate DMC chemical hazardous?

Dimethyl carbonate is mildly hazardous, with lower toxicity compared to traditional solvents and methylating agents, but it poses specific risks:

 

  1. Flammability Hazard: Highly flammable liquid and vapor (UN 1161), with risk of fire and explosion.
  2. Health Hazards: Acts as an eye and skin irritant-direct contact can cause redness, itching, or temporary corneal irritation. Inhalation of high vapor concentrations may lead to dizziness, headache, or nausea. It metabolizes to methanol in the body, so ingestion can cause methanol poisoning (e.g., visual disturbances, metabolic acidosis) in severe cases.
  3. Environmental Hazards: Low aquatic toxicity and readily biodegradable, so it has minimal long-term impact on ecosystems when handled properly.

 

 

Safety Information:

Keep containers tightly closed and store in a well-ventilated area.

Keep away from fire and do not smoke.

If contact with eyes occurs, immediately flush with plenty of water and seek medical attention.

Wear appropriate protective clothing, gloves, and eye/face protection.

 

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Dimethyl carbonate 99%

 

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