What is Flunixin Meglumine?
Flunixin meglumine is classified as a non-steroidal, anti-inflammatory drug (NSAID). It works by inhibiting the action of cyclooxygenase. The drug operates by decreasing the synthesis of prostaglandins, which are mediators responsible for inflammation and pain. By targeting the cyclooxygenase enzyme, flunixin meglumine is able to reduce the levels of these prostaglandins, thereby mitigating the associated symptoms.
Flunixin Meglumine Injection is used to reduce pain and inflammation and control fever in many species of animals like cats, cows, dogs, goats, horses. poultry, sheep, and pigs. It relieves symptoms associated with conditions like bovine respiratory disease, endotoxemia, or acute mastitis. It is also used to treat musculoskeletal pain and visceral pain associated with colic.
What are the side effects of Flunixin meglumine for horses?
The most common side effects include gastrointestinal ulcers, especially in the stomach and large colon. Horses using Flunixin meglumine may experience abdominal pain, loss of appetite, vomiting, or diarrhea. These gastrointestinal problems may cause discomfort and in severe cases may interfere with a horse's normal eating and daily activities.
In addition, the use of Flunixin meglumine may also lead to rare side effects, including kidney damage and bleeding disorders. Symptoms of kidney injury may show up in the form of decreased urine output, changes in urine color, and discomfort, which indicate that kidney function may be compromised.
Anaphylactic reactions are a rare side effect of Flunixin meglumine use, although there have been some cases reported of allergic reactions. Manifestations of an allergic reaction may include itchy skin, redness, swelling, and difficulty breathing.
Overdose
A single miscalculated dose is not likely to produce toxicity. Experimentally it has taken three to five times the normal dose over multiple days to produce toxicity.
Overdose with flunixin will increase the likelihood and severity of the mentioned side effects. Early signs of toxicity include loss of appetite and depression.
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