Ampicillin Sodium
Ampicillin sodium provides bactericidal activity against a wide range of common Gram-positive and Gram-negative pathogens. Ampicillin's activity occurs during the stage of active multiplication of the pathogen and acts through inhibition of biosynthesis of cell wall mucopeptide.In vivo studies have also demonstrated the susceptibility of many strains of the following Gram-negative bacteria: E. coli and Proteus mirabilis. Because it does not resist destruction by penicillinase, it is not effective against penicillinase-producing bacteria, particularly resistant staphylococci. Most strains of Pseudomonas, Klebsiella and Aerobacter are resistant.
Ampicillin sodium for injection is a fine powder for parenteral administration. This antibiotic is acid resistant. It can be easily absorbed when applied parenterally. Absorption may be delayed due to the long duration of plasma and tissue drug concentrations. The drug is distributed through body fluids and tissues. This antibiotic does not cross the normal blood-brain, placental, mammary or prostate barriers (only at high doses). Pregnancy in animals can increase the volume of distribution.
What is Ampicillin Sodium used for in veterinary medicine?
Ampicillin sodium is primarily used to treat a variety of infections caused by sensitive bacteria in a wide range of animals, including cattle, sheep, swine, dogs, and cats. Its common indications include:
1.Respiratory tract infections
It is suitable for the treatment of respiratory tract infections such as pneumonia and bronchitis in livestock caused by streptococcus, staphylococcus and bacillus.
2.Digestive tract infections
Good for treating digestive tract infections such as bacterial enteritis and diarrhea caused by E. coli, Salmonella, etc., especially common in piglets with digestive tract problems.
3.Urinary system infection
It is suitable for treating urinary system infections such as cystitis and pyelonephritis in cattle, sheep, pigs and other domestic animals.
4.Skin and Soft Tissue Infections
It has good therapeutic effect on skin trauma infections, abscesses, septic inflammation, etc. of domestic animals caused by sensitive bacteria.
5.Reproductive system infection
It can be used to treat uterine infections, post-partum infections and other reproductive tract problems in sows and cows, helping to restore the health of animal reproductive system.
Can Ampicillin Sodium be used in pregnant animals?
This antibiotic stands out as one of the safest options for pregnant or lactating animals. It can traverse the mother's placenta, and it remains secure for use in animals, but there are no adverse consequences for fetuses following the administration of Ampicillin.
Conclusion
As a broad-spectrum antibiotic, ampicillin sodium has become one of the drugs of choice in veterinary clinics for the management of bacterial infections due to its high efficiency and safety. By inhibiting bacterial cell wall synthesis, it can rapidly relieve the symptoms of infection and help restore the health of domestic animals.
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