Quick Answer
HPLC grade acetonitrile is an ultra-high-purity solvent specially manufactured for High-Performance Liquid Chromatography (HPLC). It typically has a purity of 99.9% or higher, extremely low UV absorbance, and minimal particulate and trace metal contamination, ensuring accurate analytical results in pharmaceutical, environmental, food, and chemical laboratories.
HPLC Grade Acetonitrile. The term HPLC stands for high performance liquid chromatography. HPLC is an analytical chemistry technique that forces a sample with pressure and pumps through a column filled with absorbent material.
HPLC Grade Acetonitrile Product Description
GNEE BIO's HPLC Grade Acetonile is a high purity solvent (> 99.9%), ideally suited for HPLC applications and general laboratory use.
Product Name: HPLC Grade Acetonitrile
Alternative Names: Methyl cyanide; Acetonitrile for HPLC; ACN; MeCN
HPLC grade acetonitrile is primarily used as a mobile phase solvent in High-Performance Liquid Chromatography for separating and analyzing complex mixtures in fields like pharmaceuticals, environmental testing, and chemical synthesis.
Why Is HPLC Grade Acetonitrile So Pure?
Unlike industrial-grade solvents, HPLC grade acetonitrile undergoes additional purification and quality control to ensure reliable chromatographic performance.
Typical quality characteristics include:
- Purity ≥99.9%
- Low UV absorbance
- Low residue after evaporation
- Low water content
- Extremely low particulate contamination
- Minimal trace metal impurities
- Consistent batch-to-batch quality
These characteristics help laboratories achieve stable baselines, improved peak shapes, and highly reproducible analytical results.
Applications of HPLC Grade Acetonitrile
HPLC grade acetonitrile is widely used in many analytical laboratories, including:
- Pharmaceutical quality control
- Drug research and development
- Environmental analysis
- Food safety testing
- Clinical laboratory analysis
- Chemical synthesis research
- Biotechnology laboratories
- University research institutions
Its excellent solvency and low UV absorbance make it one of the most commonly used mobile phase solvents for reverse-phase HPLC.
HPLC Grade vs. Industrial Grade Acetonitrile
Many users often ask about the difference between HPLC grade acetonitrile and industrial grade acetonitrile. Although both are based on the same chemical compound, they differ significantly in purity standards and intended applications.
| Grade | Typical Use |
|---|---|
| Industrial Grade | Used in chemical manufacturing, synthesis, and large-scale industrial processes where ultra-high purity and low trace impurities are not critical |
| HPLC Grade | Specifically purified for High-Performance Liquid Chromatography (HPLC), providing low UV absorbance and extremely low impurity levels to ensure accurate and reliable analytical results |
Industrial grade acetonitrile may contain higher levels of water, organic impurities, and trace contaminants. These impurities can interfere with chromatographic analysis, leading to unstable baselines or reduced sensitivity.
In contrast, HPLC grade acetonitrile CAS 75-05-8 is processed through advanced purification techniques to meet strict analytical requirements. It is widely used in laboratories to ensure high precision, excellent reproducibility, and consistent chromatographic performance.
Therefore, for any HPLC or other sensitive analytical applications, HPLC grade acetonitrile is strongly recommended over industrial grade solvent.
Where To Buy Acetonitrile Acn CAS 75-05-8?
Looking for a reliable source of high-purity Acetonitrile (ACN) CAS 75-05-8? GNEE BIO is your trusted partner for premium-grade solvents. We guarantee consistent quality, competitive pricing, and reliable global shipping. Send your inquiry today! sales@gneebio.com
about us
GNEE BIO is a professional chemical raw material supplier specializing in the global sourcing and export of solvents, chemical intermediates, and industrial chemicals. By working closely with reliable manufacturing partners, GNEE BIO provides customers with stable supply, consistent product quality, and flexible solutions for different application requirements.
With years of experience in international chemical trade, GNEE BIO has developed a strong supply chain network and professional export service system, supporting customers with product sourcing, quality documentation, logistics coordination, and customized packaging solutions.
Over the years, the company has established strong and stable partnerships with numerous domestic and international chemical groups. The company holds independent import and export rights, and its products are exported to countries and regions including Japan, South Korea, Europe, the United States, India, and Africa.
Acetonitrile Solvent Packaging
|
Weight |
Packing |
|
<25KG |
By foil-alum bag/pap/bottle |
|
≥25kg |
Package: 25kg/drum/bag or as your request |
Frequently Asked Questions
Q: Is HPLC grade acetonitrile the same as ACS grade?
A: No. HPLC grade acetonitrile is manufactured specifically for chromatographic applications and contains lower levels of UV-absorbing impurities than standard ACS or analytical grade solvents.
Q: What purity is HPLC grade acetonitrile?
A: Most HPLC grade acetonitrile has a purity of 99.9% or higher, with strict limits on water content, residue, and trace contaminants.
Q: Can HPLC grade acetonitrile be used for LC-MS?
A: For routine LC-MS analysis, many laboratories prefer dedicated LC-MS grade solvents because they contain even lower levels of ionic impurities. However, HPLC grade is suitable for many conventional chromatographic applications.
Q: What industries use HPLC grade acetonitrile?
A: It is widely used in pharmaceutical laboratories, food testing laboratories, environmental monitoring, universities, biotechnology companies, and chemical research institutes.
Q: Does GNEE BIO provide COA and MSDS?
A: Yes. COA, MSDS, TDS, and other export documentation can be provided according to customer requirements.