What solvent can replace dichloromethane?

There is no single solvent that can fully replace dichloromethane (DCM, CAS 75-09-2) in all applications.

However, depending on the process, common alternatives include ethyl acetate, acetone, methyl tert-butyl ether (MTBE), and dimethyl carbonate (DMC).

Key Alternatives by Application

Extractions

Ethyl acetate serves as a main, greener alternative for most extraction processes. MTBE is a great choice as it does not form peroxides, and 2-MeTHF is a sustainable solvent made from agricultural waste.

Chromatography

Common solvent systems include a 3:1 blend of ethyl acetate with ethanol or methanol, as well as mixtures of heptane and ethyl acetate.

Cleaning / Degreasing

Acetone, methyl ethyl ketone (MEK), and special esters work effectively as substitutes for removing paints and resins.

Reaction Solvents

Dimethyl carbonate and acetonitrile can replace DCM in certain organic reactions such as reductive amination.

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