What type of solvent is Tetrahydrofuran?
Tetrahydrofuran (THF, CAS 109-99-9) is a polar aprotic organic solvent. It is a cyclic ether with the formula C4H8O and is moderately polar, which lets it dissolve a wide range of nonpolar and polar compounds. THF is fully miscible with water and with most common organic solvents, and at low temperatures it can form solid clathrate hydrate structures with water.
What Are The Properties Of Tetrahydrofuran (CAS 109-99-9)?
| Property | Description |
|---|---|
| Chemical Formula | C₄H₈O |
| Appearance | Clear, colorless liquid |
| Odor | Ether-like, pungent, and sweet |
| Boiling Point | 66 °C (151 °F) |
| Melting Point | -108 °C (-162 °F) |
| Density | 0.8892 g/cm³ at 20 °C |
| Vapor Pressure | 132 mmHg at 20 °C (indicates high volatility) |
| Solubility | Miscible with water and most common organic solvents. |
| Flash Point | -14 °C (7 °F) - Highly Flammable |
| Auto-ignition Temp. | 321 °C (610 °F) |
What is Tetrahydrofuran Solvent used for?
THF solvent is primarily used in polymer production, chemical synthesis, PVC processing, coatings, adhesives and pharmaceutical manufacturing. Its strong solvency, polar aprotic nature and relatively low boiling point make tetrahydrofuran (THF) a versatile solvent for both industrial and laboratory applications.
- Polymer production: THF is used to produce polytetramethylene ether glycol (PTMEG), also known as PTMO or polytetramethylene oxide, through acid-catalyzed polymerization. PTMEG is an important intermediate for producing polyurethane elastomers, including spandex and other elastic fibers.
- Industrial solvent: As a polar aprotic solvent with a dielectric constant of approximately 7.6, tetrahydrofuran provides excellent solvency for many organic compounds. It is widely used in PVC processing, coatings, varnishes and adhesives, and serves as a reaction medium for Grignard reactions, polymerization and pharmaceutical synthesis.
- Coatings, inks and adhesives: THF's strong solvency and relatively low boiling point make it useful in selected coating, printing ink and adhesive formulations, particularly where rapid evaporation and effective dissolution are required.
- Chemical synthesis: Tetrahydrofuran is commonly used as a reaction solvent in organic synthesis because it can dissolve a wide range of reagents and is compatible with many commonly used reactions.
Storage and Safety
- THF is highly flammable (flash point -14 °C); keep away from ignition sources and use grounded equipment.
- It can form explosive organic peroxides on prolonged exposure to air, especially in partially filled containers. Use inhibited grades, check for peroxide content regularly, and do not distill without first testing for peroxides.
- Work in a well-ventilated area; vapor accumulation in enclosed spaces is a fire and explosion hazard.
- Store in tightly sealed containers, away from heat, sunlight and strong oxidizers.
where to Buy Tetrahydrofuran THF?
GNEE BIO is a leading supplier of CAS number 109-99-9 THF Solvent. We guarantee consistent quality, competitive pricing, and reliable global shipping to keep your operations running smoothly. For a tailored quote and product specifications, contact us today to discuss your requirements.
about us
GNEE BIO was established in 2021, adhering to thecorporate philosophy of "global chemical raw material supplier" and focusing on high-quality chemical industries. The company primarily deals chemical raw materials, such as dichloromethane; methyl sulfoxide DMSO (industrial and pharmaceutical grade); ethylene glycol (MEG); p-Xylene, etc.
All our chemical productshave obtained international certifications including REACH, ISO, FMQS, HALAL, andHalal certification, ensuring quality and global recognition.

Packaging
| Package | Quantity per 20' FCL |
|---|---|
| 160 kg drum | 12.8 MT |
| 800 kg IBC drum | 16 MT |
| ISO tank | 18.5 MT |



