Dimethyl Sulfoxide is commonly also known as DMSO. It is an organosulfur compound with the chemical formula C₂H₆OS & CAS No. 67 68 5. It features a central sulfur atom bonded to two methyl groups & also an oxygen atom. It creates a dipolar as well as aprotic solvent with remarkable miscibility in both aqueous & also organic media.
DMSO Dimethyl Sulfoxide (CAS 67-68-5) - Structure
Its chemical structure is (CH₃)₂SO, consisting of two methyl groups bonded to a sulfur atom, which is further double-bonded to an oxygen atom. This unique structure endows DMSO with excellent solubility and other distinctive physical and chemical properties.
DMSO Dimethyl Sulfoxide (CAS 67-68-5) - Purity
| Grade | Purity | Key Impurities | Typical Applications |
|---|---|---|---|
| Technical/Industrial | ≥99.0% | Water (<0.5%), DMS, traces of metals | Paints, coatings, industrial cleaning, chemical synthesis |
| ACS Reagent | ≥99.9% | Strict limits on water, non-volatile residue, acidity | Laboratory research, analytical chemistry |
| Pharmaceutical | ≥99.95% | Extremely low endotoxin, heavy metals, microbial counts | Cryopreservation, pharmaceutical intermediates |
| Spectroscopic | ≥99.98% | Deuterated (DMSO-d₆), minimal UV-absorbing impurities | NMR spectroscopy, specialized analytics |
| Electronic | ≥99.99% | Sub-ppm metal ions (Na⁺, K⁺, Fe³⁺ < 0.1 ppm) | Semiconductor cle |
DMSO Dimethyl Sulfoxide (CAS 67-68-5) - uses
1. Chemical & Organic Manufacturing
- Swern oxidation (activated DMSO with oxalyl chloride/base) for mild alcohol→aldehyde/ketone conversion
- Reactions requiring inert & high bp polar medium
2. Biochemistry & Molecular Biology
- PCR Enhancer: It diminishes secondary structures in GC rich templates (~5–10%)
- Cryoprotectant: Used at ~10% in freezing media to prevent cell damage
- Cell Differentiation Agent: Induces differentiation in P19 embryonic carcinoma cells
3. Pharmaceutical & Medical
- Off label use in interstitial cystitis through local delivery as well as under physician supervision
4. Analytical Chemistry
- NMR Solvent: DMSO d₆ is a deuterated variant (~84.17 g/mol) ideal for NMR
5. Industrial Usage
- Acts as solvent for coatings, cleaning agents as well as synthesis
- Penetration increaser in transdermal pharmaceuticals
DMSO Dimethyl Sulfoxide (CAS 67-68-5) - Safety
Safety Information:
1. It has some toxicity; avoid contact with skin and inhalation of the fumes.
2. As a flammable liquid, keep away from open flames and high temperatures.
3. Handle with care to avoid accidental ingestion or contact with eyes.
4. Prolonged or excessive contact may cause skin allergic reactions; avoid excessive exposure.
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