Dimethyl Sulfoxide is commonly also known as DMSO. It is an organosulfur compound with the chemical formula C₂H₆OS & CAS No. 67 68 5. It features a central sulfur atom bonded to two methyl groups & also an oxygen atom. It creates a dipolar as well as aprotic solvent with remarkable miscibility in both aqueous & also organic media.
DMSO Dimethyl Sulfoxide (CAS 67-68-5) - Structure
Its chemical structure is (CH₃)₂SO, consisting of two methyl groups bonded to a sulfur atom, which is further double-bonded to an oxygen atom. This unique structure endows DMSO with excellent solubility and other distinctive physical and chemical properties.
DMSO Dimethyl Sulfoxide (CAS 67-68-5) - Purity
- The purity and specification requirements of DMSO vary by grade, supplier specification and end use. The values below are typical reference ranges and should be confirmed against the applicable product specification or COA.
| Grade | Purity | Key Impurities | Typical Applications |
|---|---|---|---|
| Technical/Industrial | ≥99.0% | Water and other trace impurities | Paints, coatings, industrial cleaning, chemical synthesis |
| ACS Reagent | ≥99.9% | Strict limits on water, non-volatile residue, acidity | Laboratory research, analytical chemistry |
| Pharmaceutical | ≥99.95% | Extremely low endotoxin, heavy metals, microbial counts | Cryopreservation, pharmaceutical intermediates |
| Spectroscopic | ≥99.98% | Deuterated (DMSO-d₆), minimal UV-absorbing impurities | NMR spectroscopy, specialized analytics |
| Electronic | ≥99.99% | Sub-ppm metal ions (Na⁺, K⁺, Fe³⁺ < 0.1 ppm) | Semiconductor cleaning |
DMSO Dimethyl Sulfoxide (CAS 67-68-5) - uses
1. Chemical & Organic Manufacturing
- Swern oxidation (activated DMSO with oxalyl chloride/base) for mild alcohol→aldehyde/ketone conversion
- Reactions requiring inert & high bp polar medium
2. Biochemistry & Molecular Biology
- PCR Enhancer: It diminishes secondary structures in GC rich templates (~5–10%)
- Cryoprotectant: Used at ~10% in freezing media to prevent cell damage
- Cell Differentiation Agent: Induces differentiation in P19 embryonic carcinoma cells
3. Pharmaceutical & Medical
- FDA-approved for bladder instillation in the treatment of interstitial cystitis, administered under physician supervision.
4. Analytical Chemistry
- NMR Solvent: DMSO d₆ is a deuterated variant (~84.17 g/mol) ideal for NMR
5. Industrial Usage
- Acts as solvent for coatings, cleaning agents as well as synthesis
- Penetration increaser in transdermal pharmaceuticals
6. Agricultural & Veterinary Use
- Used as a formulation aid/penetration enhancer in certain agrochemical and topical veterinary products (e.g., equine anti-inflammatory liniments)
7. Paint & Coating Removal
- Effective solvent in industrial paint strippers and de-greasing formulations due to strong solvency power
DMSO Dimethyl Sulfoxide (CAS 67-68-5) - Safety
Safety Information:
1. Avoid unnecessary skin and eye contact and follow the handling and personal protective equipment recommendations in the SDS. DMSO can be absorbed through the skin and may increase the penetration of other substances.
2. DMSO is a combustible liquid with a relatively high flash point. Keep it away from ignition sources and excessive heat, and handle it according to the applicable SDS.
3. Handle with care to avoid accidental ingestion or contact with eyes.
4. Prolonged or repeated contact may cause skin irritation or other adverse effects. Avoid unnecessary exposure and follow the SDS recommendations.
DMSO CAS 67-68-5 - Physical Properties
| Property | Typical Value |
|---|---|
| Molecular Formula | C₂H₆OS |
| Molecular Weight | 78.13 g/mol |
| Appearance | Colorless liquid |
| Boiling Point | About 189°C |
| Melting Point | About 18.5°C |
| Water Solubility | Miscible |
| Flash Point | About 87°C |
DMSO CAS 67-68-5 - What Should Buyers Check Before Ordering?
When purchasing Dimethyl Sulfoxide (DMSO) in bulk, buyers should confirm the required purity, grade, packaging, specification and documentation before placing an order. The appropriate DMSO grade depends on the intended application, such as industrial solvents, chemical synthesis, pharmaceutical processing, laboratory use or other specialized applications.
Buyers can request a current COA to verify key quality parameters and an SDS for handling, storage and transportation information. For international shipments, packaging and transportation requirements should also be confirmed according to the destination country and order quantity.
For bulk DMSO procurement, it is useful to provide the required purity, quantity, destination port, packaging preference and target specification when requesting a quotation. This allows the supplier to recommend a suitable grade and provide a more accurate offer.
Frequently Asked Questions
Q: What is the difference between DMSO and DMSO-d₆?
A: DMSO-d₆ is the deuterated form of DMSO, where hydrogen atoms are replaced with deuterium. It is used specifically as an NMR solvent because it produces minimal interference in NMR spectra, while regular DMSO is used for general industrial, laboratory, and pharmaceutical applications.
Q: Can technical/industrial grade DMSO be used for pharmaceutical purposes?
A: No. Pharmaceutical-grade DMSO must meet strict purity requirements (≥99.95%) with controlled endotoxin, heavy metal, and microbial limits. Technical grade is not suitable for pharmaceutical or medical use.
Q: Is DMSO soluble in water?
A: Yes. DMSO is miscible with water.
Q: Can I buy DMSO in bulk?
A: Yes. Bulk DMSO procurement can be arranged according to the required purity, quantity, packaging, destination and applicable shipping requirements.
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