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Is Acetonitrile (CAS 75-05-8) Soluble in Water and Organic Solvents?

Jan 29, 2026 Leave a message

Is Acetonitrile (CAS 75-05-8) Soluble in Water and Organic Solvents?

CAS 75-05-8 Acetonitrile ACN has excellent solubility, mixing fully with water and nearly all common organic solvents like acetone, ether, chloroform and alcohol. As a polar aprotic solvent, it dissolves both polar and non-polar substances, with only poor miscibility with some saturated hydrocarbons.

 

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Solubility Features of Acetonitrile ACN

  • Water: Achieves complete miscibility, which means the two can blend in any volume ratio without separation.
  • Organic Solvents: Mixes well with alcohols, esters, acetone, ethers, chloroform and carbon tetrachloride.
  • Hydrocarbons: Fails to mix with petroleum ether and a large number of saturated hydrocarbon compounds.

 

Preparation of Acetonitrile

Acetonitrile/Methyl Cyanide is obtained as a byproduct by manufacturing acrylonitrile. It can also be synthesized by hydrogenation of mixtures of ammonia and carbon monoxide or dehydration of acetamide.

 

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