Dimethylacetamide (DMAc, CAS 127-19-5) is a polar aprotic solvent. It contains a strongly polar carbonyl group (C=O) but does not have hydrogen atoms capable of forming hydrogen bonds with solutes. Because of this structure, DMAc can dissolve many organic and inorganic compounds while remaining chemically stable in many reactions. It is commonly used in industrial applications for dissolving polymers and in organic synthesis.
| Chemical Name | N,N-Dimethylacetamide |
| Abbreviation | DMAc |
| CAS Number | 127-19-5 |
| Molecular Formula | C₄H₉NO |
| Solvent Type | Polar aprotic solvent |
| Boiling Point | ~165 °C |
| Miscibility | Miscible with water and many organic solvents |
What Is a Polar Aprotic Solvent?
Polar Aprotic Solvent refer to：
Solvents with significant dipole moments (polar molecules) that cannot form hydrogen bonds but can stabilize ions and polar molecules. Polar non-protonic solvents have extensive applications in organic synthesis and industrial chemistry.
Common polar non-protonic solvents include:
Dimethylacetamide (DMAc), Dimethylformamide (DMF), DMSO, Acetonitrile.
Applications of DMAC as a Polar Non-Protonic Solvent
Polymer and Fiber Manufacturing
Essential solvents for producing high-performance materials:
- Spandex (elastic fiber), acrylic fiber, and aramid fiber
- Polysulfone-based filtration and dialysis membranes
Pharmaceutical Industry
Applications as secondary residual solvents:
- API synthesis, purification, and crystallization
- Reaction media for antibiotics, peptides, and cardiovascular drugs
- Solvent for injectable formulations
Coatings and Adhesives
Suitable for high-temperature, high-performance coatings:
- Polyimide enameled wire insulation
- High-solids varnishes, anti-corrosion coatings, and structural adhesives
Electronics Manufacturing
- Photoresist stripper in semiconductor, PCB, and display production
- Electronic component cleaning and degreasing
Other Applications
- Petrochemical extraction distillation (styrene, butadiene)
- Agricultural chemical formulation solvent
- HPLC mobile phase modifier for polymer analysis
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CAS 64-19-7 Acetic acid/Glacial Acetic Acid; CAS 67-68-5 Dimethyl Sulfoxide (DMSO); CAS 67-63-0 Isopropyl alcohol (IPA); CAS 95-47-6 o-Xylene; CAS 106-42-3 p-Xylene; CAS 75-09-2 Dichloromethane (DCM).
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|---|---|
| Steel Drum | 160 kg |
| ISO Tank | 20–22 MT |
| IBC Tank | 800–1000 kg |
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