Dimethylacetamide DMAc (CAS 127-19-5) is a widely used high-performance organic solvent, but it is indeed listed as a hazardous chemical in many international safety regulations. Understanding its risks and handling it correctly is crucial for industrial safety.
What Is Dimethylacetamide (CAS 127-19-5)?
CAS 127-19-5 N,N-Dimethylacetamide (DMAc) is a colorless, highly polar organic solvent with excellent thermal stability, strong solubility, and good chemical inertness. It is miscible with water and most organic solvents, making it a universal medium for various complex industrial chemical reactions.
DMAc solvent is widely used in polymer and fiber production, serving as a key spinning solvent for spandex, acrylic fibers, aramid fibers, and polyimide films. It can also be used as a high-purity reaction solvent in pharmaceutical synthesis for the production of active pharmaceutical ingredients, antibiotics, and pharmaceutical intermediates.
This versatile chemical is also commonly used in semiconductor processing, industrial coatings, pesticide formulations, and petrochemical separation.
Hazard Classification
N,N-Dimethylacetamide DMAc is generally classified as: harmful by inhalation or skin absorption, skin and eye irritant, and reproductive toxicity risk (long-term exposure).
Because DMAc may have effects on human health, regulatory agencies such as the European Chemicals Agency (ECHA) and the U.S. Occupational Safety and Health Administration (OSHA) have listed it as a Substance of Very High Concern (SVHC).
| Hazard Classification | Category | H-Statement | Hazard Description |
|---|---|---|---|
| Acute toxicity (dermal) | Category 4 | H312 | Harmful in contact with skin |
| Acute toxicity (inhalation: vapors) | Category 4 | H332 | Harmful if inhaled |
| Acute toxicity (inhalation: dust/mist) | Category 4 | H332 | Harmful if inhaled |
| Reproductive toxicity | Category 1B | H360 | May damage fertility or the unborn child |
DMAC (Dimethylacetamide) Safety Data Sheet
| Category | Details |
|---|---|
| Hazard Pictograms |
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| Signal Word | Danger |
| Hazard Statements |
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| Precautionary Statements |
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Safe Handling & Storage Guidelines
Avoid skin contact: Butyl rubber gloves are recommended, as Dimethylacetamide DMAc can permeate many other types of rubber, such as latex or nitrile rubber.
Ventilation: Use only in well-ventilated areas or chemical fume hoods.
Respiratory protection: When there is an inhalation risk (concentration >10 ppm), a respirator certified by MSHA/NIOSH is required.
Protective equipment: Safety goggles, protective clothing, and a face shield should be used.
Dimethylacetamide Solvent CAS 127-19-5
Conclusion
Dimethylacetamide (DMAc) solvent (CAS 127-19-5) is indeed hazardous, especially with prolonged or repeated exposure. However, it can be safely used in a variety of industrial applications provided that appropriate safety controls are in place, personal protective equipment is worn, and applicable regulations are followed. Contact us for the complete DMAC-Dimethylacetamide-SDS.
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Gneebio Product Packaging
| Packaging Type | Net Weight |
|---|---|
| Steel Drum | 250 kg |
| IBC Tank | 1250 kg |
| ISO Tank | Bulk shipment |
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