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Is N,N-Dimethylacetamide (cas no 127-19-5) harmful?

Mar 12, 2026 Leave a message

N,N-Dimethylacetamide (DMAc, CAS 127-19-5) is harmful, DMAc may cause skin and eye irritation, respiratory discomfort, and possible liver effects with long-term exposure.

 

Possible health effects include:

  • skin irritation
  • eye irritation
  • respiratory discomfort
  • possible liver effects after long-term exposure

These risks usually occur when safety precautions are not followed or exposure levels are high.

 

Dimethylacetamide Specification Table

Chemical Name Dimethylacetamide (DMAC)
CAS Number 127-19-5
Density 0.937 g/cm³
Temperature 20 °C (68 °F)
Appearance Colorless liquid
Solvent Type Polar aprotic solvent

 

 

How to Handle DMAc Safely in Daily Operations

1. Personal Protective Equipment (PPE)
Gloves: Wear chemical-resistant gloves; butyl rubber is preferred.
Eyes: Use splash-proof goggles; or wear a face shield.
Body: Wear long-sleeved clothing, chemical-resistant aprons, or full protective suits.
Respiratory Protection: Use a fume hood; if concentrations exceed 10 ppm, wear a NIOSH-certified organic vapor respirator.

 

2. Storage
Maintain adequate ventilation to keep concentrations below exposure limits.
Store in a cool, dry, well-ventilated area with containers tightly sealed.
Keep away from heat sources, sparks, open flames, and hot surfaces.
Store separately from strong oxidizers, strong acids, aldehydes, and peroxides.

 

4. Emergency Response
Skin Contact: Rinse with copious amounts of water for at least 15 minutes.
Eye Contact: Rinse continuously with water while keeping eyes open; seek immediate medical attention.
Inhalation: Move to fresh air; seek medical attention if discomfort persists.
Spills: Absorb with inert absorbent material; use non-sparking tools; collect, seal, and dispose of properly.
Fire: Use water spray, alcohol-resistant foam, dry powder, or carbon dioxide to extinguish.

 

5. Medical Surveillance
Prolonged exposure may cause liver damage; health monitoring is recommended for regularly exposed personnel.

 

 

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Gneebio Product Packaging

 

Packaging Type Net Weight
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ISO Tank 20–22 MT
IBC Tank 800–1000 kg

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