What is Ceftiofur Hydrochloride Injection?
Ceftiofur Hydrochloride Injection is an antibiotic drug used to treat certain infections in animals such as horses, cows, goats, sheep and pigs. It is indicated for the treatment of infections like shipping fever, pneumonia, urinary tract infections, and bovine interdigital necrobacillosis.
Ceftiofur is a third-generation cephalosporin antibiotic, though some consider it a "new generation" cephalosporin. It works by inhibiting cell wall synthesis. It shows bactericidal action against a wide range of gram-positive and gram-negative bacteria, including Mannheimia, Actinobacillus, Streptococcus, Salmonella, and E. coli.
Indications and Clinical Uses
Ceftiofur Hydrochloride is used for the treatment and control of infections in cattle and swine caused by susceptible pathogens. It is registered for the treatment of bovine respiratory disease caused by Bartonella mansoni, Bartonella multocida and Bartonella somniferum (formerly Bartonella somniferum). Ceftiofur Hydrochloride is also used for the treatment of interdigital necrotizing mycobacteriosis (rotten foot disease) in cattle caused by Fusobacterium necrophorum or Bacteroides melaninogenicus.
Ceftiofur Hydrochloride has been shown to be effective at a dose of 2.2 mg/kg for the treatment of acute postpartum onychomycosis in dairy cows or by intrauterine instillation (1 g) for the treatment of retained fetal membranes. Ceftiofur Hydrochloride can be used for the treatment of SRD caused by Actinobacillus, Plasmodium multocida, Salmonella cholera, and Streptococcus suis Ceftiofur Hydrochloride and Ceftiofur Crystalline-free Acid can also be administered via the intra-udder route in dairy cows. For intramammary use, a specific formulation (Spectramast DC) is recommended. Although ceftiofur sodium has been used to treat infections in horses and dogs, there is little experience with the administration of Ceftiofur Hydrochloride in these species.