What is HPLC grade acetonitrile ACN cas 75 05 8?
CAS 75-05-8 Acetonitrile (99.9%) is a colourless, volatile, high-purity liquid that is widely used as a solvent in high-performance liquid chromatography (HPLC), pharmaceutical manufacturing and chemical analysis. It is fully miscible with water and most organic solvents, offering excellent elution capabilities and low UV absorbance for precise analytical procedures.
HPLC grade acetonitrile
Chemical Folmula: CH3CN
Molar Mass: 41.05 g/mol
Melting Point: -48°C
Boiling Point: 81-82 °C
Ignition Point: 525°C
Appearance: Clear, colourless liquid
Density @20°C (g/ml): 0.7822 – 0.786 g/ml
CAS number: 75-05-8
Structure:
| Quality Level | 100 |
| Grade | for HPLC, gradient grade |
| Vapor Density | 1.41 (vs air) |
| Vapor Pressure | 72.8 mmHg (20°C) |
| Assay | ≥99.9% |
| Autoignition Temperature | 973°F |
| Expl. Lim. | 16 % |
| baseline drift measuring range | ≤15 mAU (210 nm) |
| Impurities |
≤0.0002% free alkali (as NH3) |
| Refractive Index | n20/D 1.344 (lit.) |
| bp | 81-82°C (lit.) |
| mp | −48°C (lit.) |
| Density | 0.786 g/mL at 25°C (lit.) |
| HPLC-gradient |
≤0.5 MAU at 254 Nm |
| UV absorption |
λ: 195 Nm Amax: ≤0.12 |
| Featured Industry | Food and Beverages |
| storage temp. | room temp |
Acetonitrile 99.9% HPLC – Hazards statements
- H225 – Highly flammable liquid and vapour.
- H302 + H312 + H332 – Harmful if swallowed, in contact with skin or if inhaled.
- H319 – Causes serious eye irritation.
Why do we use Acetonitrile ACN in HPLC?
CAS 75-05-8 Acetonitrile ACN is a top HPLC solvent-here's why it's great (super simple version):
- Works better than methanol for many separations. Use less, run tests faster, less pump pressure.
- ACN-water mixes aren't thick (thinner than methanol-water). Lower pressure, faster flow, better columns.
- See-through in low UV light (down to ~190 nm). Detect more compounds that absorb far-UV.
- Mixes easy with water and other solvents. Flexible mobile phase options.
- Dries fast. Perfect for preparative HPLC and LC-MS (needs solvent removed).
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