What is HPLC grade acetonitrile CAS 75-05-8?
High-purity acetonitrile (CAS 75-05-8) for high-performance liquid chromatography (HPLC) is a specialized grade of acetonitrile designed for HPLC applications. It features extremely low moisture content, minimal UV-absorbing impurities, and negligible non-volatile residues, ensuring analytical accuracy in chromatography. This grade is widely used in laboratories requiring high-quality analytical results and adherence to stringent standards.
| Test Parameter | Specification (Typical HPLC Grade) |
|---|---|
| Purity (Assay) | ≥99.9% (by GC) |
| Residue after Evaporation | ≤1 - 5 ppm (0.0001% - 0.0005%) |
| Water Content (Karl Fischer) | ≤0.02% - 0.05% |
| UV Absorbance (Cut-off) | Specified at various wavelengths (e.g., 190–210nm) |
| UV Absorbance (Max at A₂₅₄ₙₘ) | ≤0.01 - 0.05 AU |
| Fluorescence (as Quinine Base) | ≤1.0 ppb |
| Filtered Particle Size | 0.2 μm (or 0.1 μm for Ultra-grade) |
Why is Acetonitrile (CAS 75-05-8) used in HPLC?
Acetonitrile is an ideal HPLC solvent due to its strong solubilizing power, high purity, and low viscosity, supporting efficient analyte separation.
Its chemical inertness minimizes interactions with samples and stationary phases, improving result reproducibility and data reliability.
With a relatively low boiling point, acetonitrile evaporates quickly, shortening analysis time while maintaining resolution.
Acetonitrile (CAS 75-05-8) is highly compatible with common HPLC detectors like UV and MS, thanks to its low UV cutoff and low background noise for sensitive detection.
HPLC-grade acetonitrile is preferred in chromatography due to its high purity, low UV absorption, low viscosity, and strong elution capacity, serves as the solvent of choice for chromatographic analysis. These properties enhance separation efficiency, reduce system pressure, and ensure the reliability of analytical results.
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Other Hot-Selling Products
CAS 64-19-7 Acetic acid/Glacial Acetic Acid; CAS 67-68-5 Dimethyl Sulfoxide (DMSO); CAS 67-63-0 Isopropyl alcohol (IPA); CAS 95-47-6 o-Xylene; CAS 106-42-3 p-Xylene; CAS 75-09-2 Dichloromethane (DCM).
Gneebio Product Packaging
| Packaging Type | Net Weight |
|---|---|
| Steel Drum | 160 kg |
| ISO Tank | 20–22 MT |
| IBC Tank | 800–1000 kg |
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