CAS 75-09-2 Dichloromethane (DCM) , also known as methylene chloride, is an important solvent in the pharmaceutical industry, used for extracting active pharmaceutical ingredients (APIs), synthesizing compounds such as steroids and antibiotics, and coating tablets. Its high solubility and low boiling point make it a highly efficient purification solvent.
The main properties of methylene chloride
DCM Dichloromethane liquid is colorless, transparent, volatile, has a characteristic sweet smell of ether. Slightly soluble in water, perfectly soluble in organic solvents. It is low-toxic compared to other types of solvents.
- Boiling point: 39.6°C
- Density: 1.33 g/cm³
- Melting point: -97 °C
- Flash point: 14 °C
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What is the use of dichloromethane in pharmaceuticals?
| Application | Purpose | Benefits |
|---|---|---|
| API Extraction | Isolating active ingredients from natural or synthetic sources | High purity, fast extraction |
| Reaction Medium | Solvent for intermediate reactions | Stability, minimal side reactions |
| Coating Solvent | Used in tablet film coatings | Even distribution, quick drying |
| Microencapsulation of Drugs | Encapsulation for controlled release formulations | Enhances bioavailability |
| Solvent for Lyophilization Processes | Preparation of freeze-dried injectable drugs | Low boiling, fast solvent removal |
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Safety and Handling in Pharmaceutical Use
- Use ventilated fume hoods or closed systems
- Provide PPE (gloves, goggles, respirators)
- Store in cool, ventilated, tightly sealed containers
- Follow regulatory guidelines for handling and storage
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Gneebio Product Packaging
| Packaging Type | Net Weight |
|---|---|
| Steel Drum | 250 kg |
| IBC Tank | 1250 kg |
| ISO Tank | Bulk shipment |
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