Among the most versatile and widely used polar aprotic solvents are dimethyl sulfoxide (DMSO) and dimethylformamide (DMF). Both are renowned for their ability to dissolve a wide range of polar and nonpolar compounds, making them indispensable in numerous synthetic transformations. However, their distinct physical, chemical, and toxicological properties often make one a more suitable choice over the other for a specific application.
CAS 67-68-5 DMSO vs. DMF CAS 68-12-2
| Property | DMSO (Dimethyl Sulfoxide) | DMF (Dimethylformamide) |
|---|---|---|
| Full Name | Dimethyl Sulfoxide | N,N-Dimethylformamide |
| Formula | (CH₃)₂SO | HCON(CH₃)₂ |
| Appearance | Colorless liquid | Colorless liquid |
| Boiling Point | 189°C | 153°C |
| Polarity | Highly polar aprotic | Highly polar aprotic |
| Toxicity | Low acute toxicity (but high absorption risk) | High (systemic, liver damage, reproductive risk) |
| Major Use | Cell cryopreservation, drug delivery, reaction solvent | Polymer industry, pharmaceutical synthesis, reaction solvent |
Which is more toxic, DMF or DMSO?
DMF (N,N-Dimethylformamide) is more toxic than DMSO (Dimethyl sulfoxide).
DMF: Long-term contact can damage the liver and kidneys, and affect the central nervous system (e.g., fatigue, poor memory). Skin absorption is a major risk route even without visible skin damage.
Storage: Store in a cool, dry, well-ventilated area. Keep container tightly closed and away from strong oxidizers, acids, and bases.
Why Choose Gneebio?
Choose Gneebio for consistently high-purity (≥99.9%) N,N-Dimethylformamide CAS 68-12-2, backed by batch-specific certificates. Our reliable supply chain and strict adherence to global standards (ISO, REACH)
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