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What are the properties of dimethylformamide DMF chemical?

Jan 13, 2026 Leave a message

CAS 68-12-2 N,N-Dimethylformamide (abbreviated as DMF) is a colorless, transparent liquid with strong polarity and low toxicity, making it a good organic solvent. With the rise of biopharmaceuticals, N,N-dimethylformamide (DMF) has been widely used as a solvent in the preparation of APIs and pharmaceutical intermediates.

 

What are the properties of dimethylformamide DMF chemical?

 

DMF (cas 68 12 2) Physical Properties

 

Property Value
Molecular Formula C₃H₇NO
Molecular Weight 73.09 g/mol
Appearance Colorless liquid
Odor Faint, amine-like (fishy)
Density (20°C) 0.944 g/cm³
Boiling Point 153°C (307°F)
Melting/Freezing Point -61°C (-78°F)
Flash Point (closed cup) 58°C (136°F)
Autoignition Temperature ~445°C (833°F)
Vapor Pressure (25°C) 3.7 mmHg
Refractive Index (n²⁰D) 1.430
Viscosity (25°C) 0.92 cP
Dielectric Constant (20°C) 36.7
Dipole Moment 3.86 D

 

 

dmf dimethylformamide

 

DMF (cas 68 12 2) Chemical Properties

Chemical Structure HCON(CH₃)₂ – A formamide with two methyl groups on the nitrogen.
Polar Aprotic Nature Highly polar aprotic solvent
Solubility Fully miscible with water and most organic solvents

 

What Is dMF solvent Used For?

Dimethylformamide DMF is an excellent polar aprotic solvent that is miscible with water and with most organic solvents. Because of the good property to dissolve polyethylene, polyethylene chloride, polyacrylonitrile and poly acrylamide, DMF (CAS 68-12-2) is widely used in a variety of industrial applications, such as petrochemicals, pesticides, pharmaceuticals, dyes, leather, painting and organic synthesis.

 

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