Why is Tetrahydrofuran THF used in HPLC?

Tetrahydrofuran Physical Properties:

Boiling Point: 66°C
Melting Point:-108.5°C
Density:0.889 g/cm:(20°c)
Solubility : Fully miscible with water and many organic solvents
Volatility:High vapor pressure,evaporates easily

Tetrahydrofuran THF Chemical Properties :

THF is generally chemically stable but can form explosive peroxides upon exposure to light or air.
It acts as a weak Lewis base and can react with acids.
Its cyclic structure allows it to undergo ring-opening reactions in the presence of acid or base catalysts, forming derivatives like 1,4
butanediol.

Why is Tetrahydrofuran THF used in HPLC?

THF is primarily used in HPLC because of its strong eluting strength.

• Solvent strength: In reversed-phase HPLC, THF solvent is a very strong solvent, meaning it can quickly elute strongly retained compounds from the column. This allows for shorter run times.
• Selectivity: THF belongs to a different solvent selectivity group (Group III), unlike common solvents such as methanol or acetonitrile. This gives chemists a powerful tool with which to fine-tune the separation of complex mixtures and improve peak resolution.
• UV transparency: Tetrahydrofuran (CAS 109-99-9) has a relatively low UV cutoff (~220 nm), making it suitable for UV-Vis detection at higher wavelengths.

where to Buy Tetrahydrofuran THF solvent?

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