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DMAC As A Reaction Solvent: Advantages in Organic Synthesis

Jan 26, 2026 Leave a message

CAS 127-19-5 Dimethylacetamide (DMAC), chemically known as N,N-Dimethylacetamide, is a high-purity polar aprotic solvent widely used in pharmaceutical synthesis, polymer processing, coatings, and electronic chemicals.

 

N,N-Dimethylacetamide (DMAc) is a high-performance polar aprotic solvent. It has strong dissolving power and can dissolve many organic and inorganic compounds, polymers like spandex and aramid fibres, as well as pharmaceuticals. DMAc is also thermally and chemically stable, boils at 165°C, and mixes completely with water and common organic solvents.

 

Chemical Name: N,N-Dimethylacetamide

CAS Number: 127-19-5

Molecular Formula: C₄H₉NO

EC Number: 204-826-4

 

Dimethylacetamide DMAC CAS 127-19-5 Technical Overview for Buyers
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Core Advantages as a Solvent

Dimethylacetamide DMAc's greatest strength is its exceptional solvency. It can dissolve polymers, resins and pharmaceutical active ingredients that many other solvents cannot, which is essential for making polyacrylonitrile, polyurethane and aramid fibres. Its polar aprotic nature speeds up sensitive nucleophilic reactions, such as those in drug synthesis, as it has no acidic protons to inactivate reagents. Thanks to its high boiling point and stability, it works well in high-temperature processes, boosting reaction efficiency and yields. It is also versatile, used in pharmaceuticals, electronics, coatings and adhesives.

 

Handling Precautions

CAS 127-19-5 DMAC Solvent is potentially toxic and poses reproductive risks. Users must follow safety guidelines to avoid health hazards when working with this solvent.

 

As a professional DMAC manufacturer and supplier, we provide industrial and pharmaceutical grade Dimethylacetamide with stable quality, bulk supply capability and full export documentation.

 

 

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Gneebio is a professional chemical raw materials supplier located in Henan Province, China. We have passed quality system certification and have self-managed import and export rights. Our products are popular with customers. As a leading global supplier, we deliver certified chemical raw materials that comply with REACH, RoHS, ISO and other international standards. Our robust monthly production capacity ensures consistent quality and a reliable supply for bulk orders.

 

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