CAS 127-19-5 Dimethylacetamide (DMA or DMAc) is a high-boiling (165°C),colorless, miscible polar aprotic solvent with the formulaCH3C(O)N(CH3)2. Dimethylacetamide solvent is widely used in organic synthesis, pharmaceutical manufacturing, and polymer production.
Dimethylacetamide Specification Table
| Chemical name | Dimethylacetamide |
| Abbreviation | DMA / DMAC |
| CAS Number | 127-19-5 |
| Molecular Formula | C4H9NO |
| Molecular Weight | 87.12 g/mol |
| Appearance | Colorless transparent liquid |
| Boiling Point | 165–166°C |
| Solubility | Miscible with water and most organic solvents |
Dimethylacetamide, the full name is N,N-dimethylacetamide (chemical formula: CH3C(O)N(CH3)2, abbreviated as Dmac or DMA. A commonly used aprotic polar solvent. Colorless transparent liquid, flammable. Can be used with Organic solvents such as water, alcohol, ether, ester, benzene, chloroform and aromatic compounds can be mixed at will. It is used in pharmaceuticals, synthetic resins, and is also used as a solvent for polyacrylonitrile spinning and the extraction of styrene from the carbon eight fraction. Distilled solvents, etc. are produced by the action of diamine and acetyl chloride.
What is Dimethylacetamide DMA in organic chemistry?
In organic chemistry, DMAc primarily serves as a highly efficient reaction solvent. As a polar non-protonic solvent, it finds extensive application in the following areas:
Nucleophilic Substitution Reactions: DMAc stabilizes reaction intermediates without providing protons, thereby effectively promoting the reaction process. It is commonly used in SN2 reactions, coupling reactions, and acylation reactions.
Polymer Synthesis: DMAc is extensively employed to dissolve polymers and monomers, playing a crucial role in the production of polyacrylonitrile fibers, polyimide materials, and polyurethane products.
Pharmaceutical Synthesis: High-purity DMAc is widely utilized in the preparation of active pharmaceutical ingredients (APIs), encompassing the synthesis of antibiotic intermediates, antiviral intermediates, and peptide compounds.
Industrial Applications of Dimethylacetamide DMA
Pharmaceutical Industry
Dimethylacetamide CAS 127-19-5 is used as a reaction solvent for active pharmaceutical ingredient synthesis and intermediates.
Synthetic Fibers
DMA/DMAC is a key solvent in the production of acrylic and spandex fiber products.
Coatings and Resins
DMA enhances polymer solubility and coating uniformity.
Agricultural Chemicals
N,N-Dimethylacetamide is used in the synthesis of pesticide and herbicide intermediates.
Looking for a reliable dimethylacetamide solvent (CAS 127-19-5) Supplier or manufacturer? Contact us for bulk supply, COA, SDS and competitive pricing.
Get Your Quote or Place Your Order Today!
High-Purity DMAC Solvent Supplier
about us
As a leading manufacturer and exporter of fine chemicals, Henan Gneebio provides high-quality industrial chemicals. We supply to customers across the chemical, pharmaceutical, and materials industries, ensuring consistent quality, reliable logistics, and professional technical support.
Our chemical products hold international certifications (REACH, ISO, FMQS, HALAL) for global quality recognitio. We have warehouses in coreports such as Qingdao, Tianiin, and Shanghai, with a 15-day express delivery service.
Other Hot-Selling Products
CAS 64-19-7 Acetic acid/Glacial Acetic Acid; CAS 67-68-5 Dimethyl Sulfoxide (DMSO); CAS 67-63-0 Isopropyl alcohol (IPA); CAS 95-47-6 o-Xylene; CAS 106-42-3 p-Xylene; CAS 75-09-2 Dichloromethane (DCM).
Gneebio Product Packaging
| Packaging Type | Net Weight |
|---|---|
| Steel Drum | 160 kg |
| ISO Tank | 20–22 MT |
| IBC Tank | 800–1000 kg |
Customer Visit
