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What is the solubility of dimethylacetamide DMAc (CAS 127-19-5)?

Mar 10, 2026 Leave a message

The solubility of dimethylacetamide (DMAc, CAS 127-19-5) is completely miscible with water and most organic solvents. DMAC is completely miscible (soluble in all proportions) with water, alcohols, ethers, esters, aromatics, ketones, and chloroform.

 

CAS 127-19-5 N,N-Dimethylacetamide is a highly polar, colorless liquid, it serves as a powerful solvent for many organic compounds and polymers, although it has poor solubility in aliphatic hydrocarbons. Dimethylacetamide DMAc is widely used polar aprotic solvent in chemical synthesis and polymer processing.

 

 

Specification Table

Chemical Name Dimethylacetamide (DMAC)
CAS Number 127-19-5
Appearance Colorless liquid
Solubility in Water Completely miscible
Solubility in Organic Solvents Miscible with most organic solvents
Solvent Type Polar aprotic solvent

 

 

Why DMAc Has High Solubility

DMAc has the molecular structure CH₃CON(CH₃)₂, which contains:

  • a carbonyl group (C=O)
  • a dimethylamine group
  • These functional groups create a strong dipole moment, allowing DMAc to interact with many molecules through dipole-dipole interactions and hydrogen bonding.

 

Methyl substitutions improve organic solubility and lower reactivity, stabilizing polymer solutions.It is also fully miscible with water, making it versatile for both aqueous and organic systems.

 

As a result, DMAc shows excellent solvating power for:

  • organic compounds
  • polymers
  • pharmaceutical intermediates

 

 

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