Dimethylacetamide (CAS 127-19-5), abbreviated as DMAc/DMA, is a colorless, water-soluble liquid with the molecular formula CH3CON(CH3)2. It is a high-boiling-point polar aprotic solvent used in the production of synthetic fibers, plastics, and pharmaceuticals.
Molecular Structure of dimethylacetamide (CAS 127-19-5)
Molecular formula: C₄H₉NO
Structural formula: CH₃–CO–N(CH₃)₂
Structure visualization: CH3-CO-N(CH3)2
Its structure features is : a central amide group where two hydrogen atoms on the nitrogen are replaced by two methyl groups.
What does this structure mean?
Due to this structure, N,N-Dimethylacetamide DMAc possesses:
- High polarity (favorable for dissolving polymers)
- Ability to dissolve organic compounds and some inorganic compounds
- High boiling point and thermal stability
- Low volatility compared to lighter solvents
What are the properties of DMAC solvent?
| Properties | |
|---|---|
| Molecular Weight | 87.12 |
| Boiling Point (°C at 760 mmHg) | 165.5 |
| Freezing Point (°C) | -20 |
| Density (at 15.6 °C) | 0.9448 |
| Heat of Vaporization | 10.36 kcal/gr.mole |
| Heat of Combustion | 608 kcal/gr.mole |
| Flash Point (°C) | 490 |
| Heat of Formation (Liquid, 0.87 °C) | 0.485 cal/gr. °C |
| Combustion Limits |
Minimum: 2% by volume Maximum: 11.5% by volume |
| Solubility | Fully miscible with water, ether, esters, ketones, and aromatic compounds |
| Hydrolysis Tendency | Tends to hydrolyze in aqueous solutions at high temperatures |
What is N,N-dimethylacetamide (CAS 127-19-5) used for?
Pharmaceuticals: Dimethylacetamide DMAc is used as a reaction medium in active pharmaceutical ingredient (API) synthesis and peptide coupling processes, where purity and consistency are critical.
Polymer Production: Utilized in manufacturing polyimide, polyacrylonitrile, and polyurethane for advanced fibers, membranes, and films.
Electronics: N,N-Dimethylacetamide (CAS 127-19-5) is used as a cleaning and coating solvent for semiconductors and display materials.
Agricultural Chemicals: In pesticide and herbicide formulation due to its excellent solvency for complex active ingredients.
Dimethylacetamide Solvent CAS 127-19-5
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