Dimethyl acetamide cas no 127-19-5 is a high-performance polar aprotic solvent extensively used in the chemical industry for producing acrylic fibers, spandex, and polyamides. It serves as a reaction medium in pharmaceutical manufacturing, a solvent for paints, and an agent in adhesives and electronics.
DMAc Technical Data Sheet
| Parameter | Specification |
|---|---|
| Product Name | N,N-Dimethylacetamide |
| Other Names | DMAc, Dimethyl acetamide |
| CAS Number | 127-19-5 |
| Molecular Formula | C₄H₉NO |
| Molecular Weight | 87.12 g/mol |
| Appearance | Colorless transparent liquid |
| Purity | ≥99.5% |
| Density | 0.936 g/cm³ (20°C) |
| Boiling Point | 164–166°C |
| Melting Point | −20°C |
| Flash Point | 66–70°C (Closed cup) |
| Refractive Index | 1.437–1.439 (20°C) |
| Solubility | Miscible with water and most organic solvents |
| Vapor Pressure | 1.3 mmHg (20°C) |
| Water Content | ≤0.05% |
| Acidity (as Acetic Acid) | ≤0.005% |
| Residue on Evaporation | ≤0.005% |
What is dimethyl acetamide cas no 127-19-5 used for?
Dimethylacetamide (DMAC) is a high-boiling-point, polar non-protonic solvent characterized by strong solubility, excellent thermal and chemical stability, and low corrosivity. It finds extensive applications across numerous industries as a critical reaction medium, processing solvent, and cleaning agent.
In the fiber and textile industry, dimethyl acetamide (CAS No. 127-19-5) is primarily used in the production of spandex, acrylic, aramid fibers, and cellulose-based materials. It serves as a key spinning solvent in both wet and dry spinning processes.
In pharmaceutical applications, Dimethylacetamide Solvent serves as a vital solvent and reaction medium for synthesizing, crystallizing, and purifying active pharmaceutical ingredients, antibiotics, peptides, and contrast agents. It is also employed in manufacturing medical dialysis membranes.
In polymer and plastics production, DMAC dissolves and processes high-performance polymers like polyimides, polysulfones, and polyamides. It also serves in adhesive and coating formulations, as well as graphene exfoliation processes.
Within the electronics industry, its high cleaning efficiency and gentle impact on equipment make it widely used for wafer cleaning, photoresist stripping, LCD manufacturing, and printed circuit board processing.
In petrochemical and chemical synthesis applications, dimethyl acetamide (CAS No. 127-19-5) serves as an extraction solvent for separating hydrocarbon mixtures, facilitates natural gas desulfurization and decarbonization, and functions as a high-temperature reaction solvent in coupling, condensation, and acylation reactions.

Why Industrial Buyers Choose DMAc solvent?
For chemical manufacturers and industrial buyers, DMAc presents numerous notable advantages.
1. Dimethyl acetamide cas no 127-19-5 exhibits outstanding solvency capabilities, enabling it to dissolve a wide range of substances such as polymers, inorganic salts, and various organic compounds.
2. Featuring a boiling point of approximately 165°C, DMAc is well‑suited for high‑temperature chemical reactions and industrial processing.
3. Additionally,dimethylacetamide solvent demonstrates strong chemical stability under diverse reaction conditions, rendering it highly reliable for complex chemical synthesis.
Which industries use DMAC solvent?
| Industry | Use |
|---|---|
| Polymer manufacturing | Polyurethane, polyimide, fibers |
| Pharmaceuticals | Reaction solvent for synthesis |
| Electronics | Battery and semiconductor materials |
| Chemical manufacturing | Specialty reactions and intermediates |
| Coatings and adhesives | Resin and formulation solvent |
Safe handling and Storage
| Safe Handling | Use adequate ventilation, wear protective gloves and goggles, and adopt closed transfer systems. |
| Storage | Store in sealed containers, keep in cool and well-ventilated areas, and keep away from oxidizing agents. |
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FAQ
Why is DMAc used as a solvent?
Dimethyl acetamide DMAC is a dipolar aprotic solvent used for many organic reactions and industrial applications. It is a versatile solvent due to its high boiling point and good thermal and chemical stability.
Is dimethylacetamide used in pharmaceutical industry?
N,N-Dimethylacetamide DMAC solvent is an important pharmaceutical raw material widely used in the production of drugs such as amoxicillin and cephalosporins. It acts as a solvent or co-catalyst and offers improved product quality and yield compared to traditional organic solvents.
DMAC plays a vital role in manufacturing pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
What purity grades of dimethylacetamide are available?
DMAc is available in several grades depending on the application, including:
- industrial grade
- pharmaceutical grade
- electronic grade
- high-purity laboratory grade
Purity Levels: Common concentrations include 98.5%, 99%, 99.5%, 99.8%, and 99.9%.
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Gneebio Product Packaging
| Packaging Type | Net Weight |
|---|---|
| Steel Drum | 160 kg |
| ISO Tank | 20–22 MT |
| IBC Tank | 800–1000 kg |

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