CAS 127-19-5 Dimethylacetamide (DMAC or DMA) is an FDA-approved, high-polarity aprotic solvent used in the pharmaceutical industry. It is commonly applied in drug synthesis, pharmaceutical intermediates production, reaction media for organic synthesis, and purification processes. Due to its strong solvating ability, high boiling point, and chemical stability, DMAc helps improve reaction efficiency and supports the manufacturing of complex pharmaceutical compounds.
Dimethylacetamide (DMAc) Pharmaceutical Grade Specifications
| Product Name | Dimethylacetamide |
| Synonyms | DMAc, N,N-Dimethylacetamide |
| CAS Number | 127-19-5 |
| Molecular Formula | C₄H₉NO |
| Molecular Weight | 87.12 g/mol |
| Grade | Pharmaceutical Grade |
| Appearance | Colorless clear liquid |
| Assay (GC) | ≥ 99.9% |
| Water Content (Karl Fischer) | ≤ 0.05% |
| Acidity (as Acetic Acid) | ≤ 0.003% |
| Basicity (as Dimethylamine) | ≤ 0.002% |
| Residue on Evaporation | ≤ 0.002% |
| Heavy Metals | ≤ 10 ppm |
| Iron (Fe) | ≤ 0.5 ppm |
| Color (APHA) | ≤ 10 |
| Density (20°C) | 0.935 – 0.940 g/cm³ |
| Refractive Index (20°C) | 1.437 – 1.439 |
| Boiling Point | 164 – 166 °C |
| Flash Point | 66 – 70 °C |
What are the uses of Dimethylacetamide solvent in the pharmaceutical industry?
Key Applications of Dimethylacetamide in the Pharmaceutical Industry
1. Reaction Solvent in Drug Synthesis
One of the most common applications of dimethylacetamide solvent in the pharmaceutical industry is as a reaction solvent for organic synthesis. Its ability to dissolve various organic reagents and catalysts, stabilize reaction intermediates, and support high-temperature reactions makes it suitable for synthesizing pharmaceutical intermediates and active compounds.
2. Pharmaceutical Intermediate Production
N,N-Dimethylacetamide DMAc is extensively used in the production of pharmaceutical intermediates, which serve as critical building blocks in drug manufacturing. It enhances reaction yields and improves reactant solubility. Numerous fine chemical and API manufacturers rely on DMAc to accomplish complex intermediate reactions.
3. Peptide and Specialty Molecular Synthesis Solvent
Dimethylacetamide solvent is frequently employed in synthesizing peptides and complex organic molecules due to its ability to dissolve: amino acid derivatives, catalysts, and specialty reagents.
4. Pharmaceutical Process Development
During drug R&D and process optimization phases, DMAc is extensively utilized in laboratory and pilot-scale studies.
Typical Pharmaceutical Applications
| Application | USE |
|---|---|
| API synthesis | Reaction solvent |
| Pharmaceutical intermediates | Reaction medium |
| Drug development | Laboratory solvent |
| Organic synthesis | Polar aprotic solvent |
| Process chemistry | Reaction optimization |
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FAQ
Is dimethylacetamide Solvent suitable for API production?
Yes, N,N-Dimethylacetamide (DMAc or DMAC) is considered suitable for Active Pharmaceutical Ingredient (API) production, particularly as a reaction medium, extraction solvent, and crystallization agent.
What purity of DMAc solvent is required for pharmaceutical manufacturing?
Typically requires a high-purity grade, generally 99.9%.
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| Packaging Type | Net Weight |
|---|---|
| Steel Drum | 160 kg |
| ISO Tank | 20–22 MT |
| IBC Tank | 800–1000 kg |
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