Ivermectin is a drug obtained by chemical modification of a derivative of avermectin. It is a broad-spectrum antiparasitic drug mainly used in domestic animals and pets for internal and external parasitic infections, including nematodes, mites, ticks, fleas and so on. The mechanism of action of ivermectin is by interfering with the parasite's nervous system, causing paralysis and eventual death.
Avermectin is a naturally sourced antibiotic compound produced by Streptomyces and belongs to the class of macrolides. Avermectin also has a broad-spectrum antiparasitic effect and is primarily used for the control of internal and external parasites. Similar to ivermectins, avermectins also work by acting on the nervous system of the parasite, causing paralysis and death.
What is the difference between Ivermectin and Avermectin?
Definition
Ivermectin belongs to the group of macrolides. Meanwhile, avermectin is a class of natural compounds extracted from the soil bacteria Streptomyces avermitilis.
Chemical structure
Ivermectin is a derivative of avermectin and its chemical structure is slightly altered compared to the parent compound.
Differences in dosage forms and modes of use
Ivermectin: Ivermectin is often available in a variety of forms such as injections, oral solutions, transdermal solutions and powders, making it flexible for use.
Avermectin: Avermectin is usually available as an injection, transdermal solution or feed additive and is administered mainly by injection or transdermal absorption.
Conclusion
The main difference between ivermectin and avermectin is that ivermectin is a broad-spectrum antiparasitic drug, whereas avermectin is a class of macrocyclic lactones produced by Streptomyces, which are used in medicine to kill parasites.