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Why is dichloromethane (CAS 75-09-2) a good solvent for extraction?

Mar 19, 2026 Leave a message

CAS No 75-09-2 Dichloromethane (DCM) is an excellent extraction solvent due to its low boiling point, which allows for easy removal, and its high volatility. It is a moderately polar, aprotic solvent that readily dissolves a wide range of organic compounds while remaining immisicible with water, enabling easy separation in liquid-liquid extraction.

 

Dichloromethane (DCM) Specifications Table

Property Details
CAS Number 75-09-2
Chemical Name Methylene Chloride (Dichloromethane)
Molecular Formula CH2Cl2
Appearance Clear, colorless liquid
Odor > Pleasant, mild, ether-like
Molecular Weight 84.93 g/mol
Boiling Point 39.6–40.0 °C
Melting Point −96.7 °C
Density (20 °C) 1.325–1.330 g/cm³
Refractive Index (20 °C 1.4240–1.4250
Vapor Pressure (20 °C) ~350–390 mmHg
Flash Point Non-flammable
Water Solubility (20 °C) .3 g/L (sparingly soluble)
Purity (%) ≥99.8 %
Main Impurities Methanol, chloromethane, trichloromethane
Typical Color ASTM ≤2.0

 

 

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Why is dichloromethane (CAS 75-09-2) a good solvent for extraction?

1. Excellent solubility in organic compounds
Dichloromethane (DCM) has moderate polarity, thus it can dissolve a wide variety of organic compounds.

 

2. Immiscible with water
Methylene Chloride is immiscible with water, therefore a distinct organic layer forms during extraction.

 

3. High density (heavier than water)
Dichloromethane has a density of approximately 1.33 g/cm³, which is heavier than water, thus forming a bottom layer in a separatory funnel.

 

4. Low boiling point (easy to separate)
DCM has a boiling point of approximately 39.6°C. This low boiling point makes the solvent easily removed by evaporation or rotary evaporation.

 

5. Fast extraction kinetics
Dichloromethane (DCM) has low viscosity and strong diffusivity.

 

6. Low reactivity
It is chemically stable and has relatively low reactivity with most solutes.

 

7. Superior Phase Separation Compared to Other Solvents

Compared to solvents such as ethyl acetate, dichloromethane produces less emulsion and forms clearer, more separated layers.

 

8. Wide Range of Industrial and Laboratory Applications

DCM is widely used in drug extraction, natural product separation, and post-reaction processing in chemical synthesis.

 

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