Is acetonitrile (CAS 75-05-8) a safe solvent?
Acetonitrile is a widely used, highly effective industrial and laboratory solvent, but it is not considered safe without strict safety precautions. It is toxic, flammable, and can be absorbed through the skin, releasing cyanide in the body.
safety information for acetonitrile (CAS 75-05-8)
Toxicity
The solvent is metabolized into hydrogen cyanide in the body, which can cause headaches, dizziness, nausea and other symptoms. Severe exposure to acetonitrile may even lead to death.
Exposure routes
Acetonitrile is hazardous to the human body if inhaled, swallowed, or absorbed through the skin contact.
Flammability
It is highly flammable with a flash point of 2°C, and must be stored away from heat sources and open flames.
Handling requirements
Always use acetonitrile in a chemical fume hood, wear protective gloves such as butyl rubber gloves, and use eye protection equipment at the same time.
Emergency measures
In case of exposure, remove contaminated clothing immediately and wash the exposed skin with water. Seek medical help at once, because the cyanide-related harmful effects of acetonitrile may have a delayed onset.
Although acetonitrile has lower toxicity than some other nitriles, it still brings significant health risks. Strict safety operation rules must be followed when using this solvent.
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