Is THF Tetrahydrofuran (CAS 109-99-9) toxic to humans?

What is Tetrahydrofuran THF (CAS 109-99-9)?

THF Tetrahydrofuran is an organic compound with the formula (CH2)4O. The compound is classified as heterocyclic compound, specifically a cyclic ether. It is a colorless, water-miscible organic liquid with low viscosity. It is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF (CAS 109-99-9) is a versatile solvent. It is an isomer of another solvent, butanone.

Is THF Tetrahydrofuran (CAS 109-99-9) toxic to humans?

THF is toxic to humans and requires careful handling.

• Acute toxicity: Inhalation causes irritation of the eyes, nose and throat, and central nervous system (CNS) depression leading to dizziness, drowsiness, headache, and nausea. High concentrations can cause unconsciousness.
• Chronic toxicity: Prolonged or repeated exposure causes liver and kidney damage, and dermatitis by defatting the skin.
• Carcinogenicity: Some health agencies classify THF as a suspected carcinogen due to evidence from animal studies, primarily through inhalation exposure.

What is Tetrahydrofuran THF used for?

1. Tetrahydrofuran is used as a solvent and raw material for organic synthesis
2. THF is used as a chromatographic analysis reagent, organic solvent, and nylon intermediate
3. Tetrahydrofuran, also known as oxoalkanes, oxoalkanes, and tetramethylene oxide, is an intermediate in the synthesis of pesticide phenylbutyltin.
4. In addition, it can also be directly used to manufacture synthetic fibers, synthetic resins, and synthetic rubbers. Polymer materials, precision tapes, and solvents in the electroplating industry.
5. Tetrahydrofuran CAS 109-99-9 is also used in the production of adipic nitrile, adipic acid, adipic diamine, succinic acid, butanediol γ- Butyrolactone and can be used in the pharmaceutical industry.

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