CAS 141-78-6 Ethyl acetate (EtOAc) is one of the most widely used organic solvents in coatings, pharmaceuticals, adhesives, and food processing. What solvents are similar to ethyl acetate? Solvents similar to ethyl acetate (EA) include acetone, methyl acetate, methyl ethyl ketone (MEK), and tetrahydrofuran (THF), which have similar polarity or evaporation rates.
Key Characteristics of Ethyl Acetate
Before comparing other solvents, it is crucial to understand the properties of ethyl acetate solvent:
- Semi-polar solvent
- Fast evaporation rate
- Good solubility in resins, oils, and polymers
- Relatively low toxicity
- Pleasant odor

Key Properties of Solvent ethyl acetate
| Chemical Formula | C₄H₈O₂ |
| Molecular Weight | 88.11 g/mol |
| CAS No. | 141-78-6 |
| Appearance | Colorless liquid |
| Odor | Sweet, fruity |
| Density (20°C) | 0.897 g/cm³ |
| Boiling Point | 77.1°C |
| Melting Point | -83.6°C |
| Vapor Pressure (20°C) | ~73 mmHg |
| Evaporation Rate | Fast |
| Water Solubility | 8.3 g/100 mL |
| Organic Solubility | Miscible with most organics |
| Polarity | Moderate |
| Flash Point | -4°C |
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What is a solvent similar to ethyl acetate solvent?
The most common substitutes solvent include acetone, methyl acetate, tetrahydrofuran (THF), and dichloromethane (DCM).
| Ethyl Acetate | Acetone | Methyl Acetate | Tetrahydrofuran (THF) | Dichloromethane (DCM) | |
|---|---|---|---|---|---|
| Chemical Type | Ester | Ketone | Ester | Ether | Chlorinated solvent |
| CAS Number | 141-78-6 | 67-64-1 | 79-20-9 | 109-99-9 | 75-09-2 |
| Polarity | Medium | High | Medium | Medium-High | Medium |
| Evaporation Rate | Medium-Fast | Very Fast | Fast | Medium-Fast | Medium |
| Boiling Point (°C) | 77.1 | 56 | 57 | 66 | 39.6 |
| Solvency Power | Good | Strong | Good | Very Strong | Very Strong |
| Water Miscibility | Slight | Completely miscible | Slight | Completely miscible | Slight |
| Flammability | Highly flammable | Highly flammable | Highly flammable | Highly flammable | Non-flammable |
| Toxicity Level | Low | Moderate | Low | Moderate | Higher |
| Environmental Impact | Relatively eco-friendly | VOC contributor | Relatively eco-friendly | VOC contributor | Environmental concern |
Summary
- Methyl acetate is the closest direct substitute
- Acetone is ideal for fast evaporation and cleaning
- THF is better for high-performance and polymer applications
- DCM offers strong solvency but comes with environmental and safety concerns
Choosing the right alternative depends on your formulation needs, safety requirements, and regulatory constraints.
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People also ask
How do I choose the right solvent?
Choosing the right solvent is like picking the best tool for a job. You should think about how well the solvent can dissolve materials, how quickly it dries, its boiling point, and safety concerns such as how flammable it is. Also, consider the smell and whether it works well with the materials you're using.
Is Ethyl Acetate safe for humans?
At low concentrations, ethyl acetate (EA) liquid is generally safe for people, especially in products like food flavorings and cosmetics. However, at higher concentrations, EtOAc can be harmful and cause irritation to the skin, eyes, and respiratory system.
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Gneebio Product Packaging
| Packaging Type | Net Weight |
|---|---|
| Steel Drum | 250 kg |
| IBC Tank | 1250 kg |
| ISO Tank | Bulk shipment |

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