What Is the Solubility of Acetonitrile CAS 75-05-8?

Acetonitrile (CAS 75-05-8) is completely miscible with water and is also soluble in most organic solvents such as alcohols, ethers, and hydrocarbons. "Completely miscible" means acetonitrile can mix with water in any proportion without phase separation.

Organic Solvents: Acetonitrile is miscible with alcohols (methanol, ethanol), acetone, ethers, esters (ethyl acetate), benzene, chloroform, carbon tetrachloride, and many unsaturated hydrocarbons.

Not Misicible with: It is generally immiscible with many saturated hydrocarbons, such as petroleum ether.

Why is the solubility of acetonitrile important?

CAS 75-05-8 Acetonitrile's unique solubility makes it indispensable across numerous industries:
High-Performance Liquid Chromatography (HPLC): Fully miscible with water, low viscosity, and UV-transparent, it is ideal for reverse-phase HPLC with low back pressure and high sensitivity.
Pharmaceutical Manufacturing: Used for the synthesis, purification, and crystallization of drugs and active pharmaceutical ingredients (APIs) that are poorly soluble in water.
Chemical extraction: Selectively dissolves target compounds for petrochemical separation, lipid purification, and industrial degreasing.
Organic synthesis: As a polar, non-protonic solvent, it supports water-sensitive reactions, including DNA/oligonucleotide production.
Battery technology: Exhibits excellent electrolyte solubility, widely used in lithium-ion batteries and electrochemical cells.

Is acetonitrile CAS 75-05-8 a polar solvent?

CAS 75-05-8  Acetonitrile (CHCN, ACN) is a relatively nontoxic, highly volatile and aprotic polar organic solvent. It is the simplest organic nitrile. This colorless and polar aprotic solvent is used for organic synthesis and purifications, and to extract fatty acids from oils.

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